Dr. Orlando, MD MHS MMCI is a Professor of Medicine and Director of the Precision Medicine Program at Duke University. She attended Tulane Medical Center for both medical school (1994-1998) and Internal Medicine residency (1998-2000). There she finished AOA and received a number of awards for teaching and clinical care from the medical school and the residency programs, including the Musser-Burch-Puschett award in 2000 for academic excellence. After completing her residency, she served as Chief Medical Resident in Internal Medicine (2001) and then completed a Health Services Research Fellowship at Duke University Medical Center (2002-2004). In 2004 she also received her MHS from the Clinical Research Training Program at Duke University and joined the academic faculty. In 2005 she received the Milton W. Hamolsky Award for Outstanding Junior Faculty by the Society of General Internal Medicine. Her major research interests are patient preferences, decision modeling, implementation research, translating genomic medicine to clinical care, and risk assessment for prevention.

From 2004-2009 Lori worked with Dr. David Matchar in the Center for Clinical Health Policy Research (CCHPR), where she specialized in decision modeling, decision making, and technology assessments. In 2009 she began working with Dr. Geoffrey Ginsburg in what is now the Center for Applied Genomics and Precision Medicine (CAGPM) and in 2014 she became the director of the Center’s Precision Medicine Program. Since joining the CAGPM she has led the development and implementation of MeTree, a patient-facing, family health history based risk assessment and clinical decision support program designed to facilitate the uptake of risk stratified evidence-based guidelines.

MeTree was designed to overcome the major barriers to collecting and using high quality family health histories to guide clinical care and has been shown to be highly effective when integrated into primary care practices. This effort started with the Genomic Medicine Model, a multi-institutional project, whose goal was to implement personalized medicine in primary care practices. The success of that project has led to funding as part of NHGRI’s IGNITE (Implementing Genomics in Clinical Practice) and eMERGE (Electronic Medical Records and Genomics) networks. As much of this work involved technology and informatics Lori obtained an MMCI degree from Duke University in 2019. She is currently leading efforts in methods for integrating technology with patient care using FHIR data standards and integrating patient preferences and decision making processes into clinical decision support recommendations for patients and providers to facilitate management of patients’ risk.

Lori is the President of MeTree&You. She has national and international expertise in family history based risk assessment and she is frequently approached by individuals and companies interested in using MeTree. She identifies clients, facilitates outreach, and oversees application design, features, and capabilities.

Ms. Rakhra-Burris has a Bachelors of Science in business administration from the University of Vermont and a Masters of Art in Molecular Genetics from Washington University in St. Louis. She has over 20 years of experience in administration and program management of scientific research in higher education, with specific experience in managing projects in the fields of precision medicine, pharmacogenomics and individualized therapy, and public health genetics. She is currently on a sabbatical of self-discovery, but previously was an Associate in Research with the Duke University School of Medicine Precision Medicine Program. Additionally she was the Program Manager of the Duke University Clinical Group participation in the IGNITE Network, and oversaw proposal development, management and implementation of clinical research efforts, including research using MeTree®. In 2018, she became the Executive Director of the Global Genomic Medicine Collaborative (GGMC) and was appointed as the President and CEO of that organization in 2023. She directed the GGMC Secretariat in its responsibility for the administrative and executive services for the GGMC, providing leadership and oversight of all programmatic activities, personnel/contractors, and meetings conducted by the Secretariat. She stepped down as CEO in June 2024.

Relevant to MeTree&You, Inc. since Ms. Rakhra-Burris joined Duke University in 2011 she has been involved with the development and use of MeTree Family Health History software in research programs at Duke University, led by Dr. Orlando, and has worked closely with the programming team of One Cow Standing to manage activities, both financial and the software development needs of the research projects.

Dr. Wu, MD, MHS is an Associate Professor of Medicine in the Precision Medicine Program at Duke University with over 14 years experience as a primary care physician and researcher with a focus on implementation of precision medicine interventions. She has been an integral member of the MeTree research team since 2012, working closely with primary care physicians across multiple healthcare systems on the implementation and evaluation of MeTree. Dr. Wu spent three years in Singapore where she was the MeTree team lead for integration of the platform into a large population health sequencing program and led the first pilot of MeTree in an oncology setting. Dr. Wu leads the guideline review and clinical decision support development for MeTree&You.

Dr. Wu received her Bachelors of Science from Duke University with a major in Psychology (2001). She completed her medical degree at the University of North Carolina at Chapel Hill (2006). She then completed residency and was selected as chief resident for Internal Medicine at Georgetown University (2006-2010), followed by a fellowship in health services research at Duke University (2012-2014). During her fellowship, she completed a Masters of Health Sciences through Duke’s Clinical Research Training Program

Dr. Hauser, PhD, MS, MHS is a Professor in the Department of Biostatistics and Bioinformatics at Duke University. She holds graduate degrees in Biostatistics and Epidemiology with a focus on human genetics. Her research interests include statistical methods development for the analysis of complex genetic traits, analysis of family data, gene-environment interactions, and integrated analysis of metabolomics and genomic data. She has worked on studies of cardiovascular disease, diabetes, aging, and cancer. She has nearly 40 years of research experience and published over 180 articles. She has worked with Dr. Orlando on research related to family health history since 2007.

Dr. Ginsburg, MD, Phd is the Chief Medical and Scientific Officer of the All of Us Research Program at the National Institutes of Health. He leads the Division of Medical and Scientific Research and is responsible for helping to set the scientific vision and strategy for the program. He also oversees the program’s collection and curation of data, and integration of new data types to support a wide range of impactful scientific discoveries. Prior to joining All of Us, Ginsburg was founding director for the Center for Applied Genomics & Precision Medicine in the Duke University School of Medicine where he pioneered translational genomics and the development of novel diagnostics. At Duke, he was Professor of Medicine, Biostatistics and Bioinformatics, Pathology, and Biomedical Engineering. He was also a Professor in School of Nursing; he will remain an Adjunct Professor of Medicine. He has also held senior leadership roles at Millennium Pharmaceuticals Inc. and was a member of the Harvard Medical School faculty.